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pentobarbital will minimize the extent or impact of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.Contraindicated (1)pentobarbital will lower the extent or influence of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration. Rob